Reacción #69971

Ecuación de reacción

4-bromophenylpiperazine

triethylamine

benzyl chloroformate

→

4-(4-bromophenyl)piperazine-1-carboxylic acid benzyl ester

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture is cooled in an ice bath
2. 2
   Otroto return to ambient temperature
3. 3
   Otrogentle hydrolysis
4. 4
   ExtracciónThe aqueous phase is extracted with dichloromethane
5. 5
   Lavadowashed with a saturated NaCl solution
6. 6
   Secadodried over sodium sulphate
7. 7
   Filtraciónfiltered through a sintered glass
8. 8
   Filtraciónfilter
9. 9
   Concentraciónconcentrated under vacuum

Procedimiento

5 g of 4-bromophenylpiperazine are placed in a 500 ml three-necked flask under a nitrogen atmosphere. 4.34 ml of triethylamine are added. The mixture is cooled in an ice bath and 3.24 ml of benzyl chloroformate are added. The mixture is allowed to return to ambient temperature. It is diluted with dichloromethane and then gentle hydrolysis is carried out. The aqueous phase is extracted with dichloromethane. The organic phases are combined, washed with a saturated NaCl solution, dried over sodium sulphate, then filtered through a sintered glass filter and concentrated under vacuum. 8.43 g of 4-(4-bromophenyl)piperazine-1-carboxylic acid benzyl ester are obtained.

Fuente