Reacción #69970

Ecuación de reacción

hydrochloric acid

4-[4-(4-(methanesulphonyl)piperazin-1-yl)phenyl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid

→

1-[4-(4-(methanesulphonyl)piperazin-1-yl)phenyl]-1,2,3,4-tetrahydroquinoxaline

Disolventes

dichloromethane

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvents are evaporated under reduced pressure
2. 2
   workup.ADDITIONWater, a saturated aqueous sodium hydrogencarbonate solution and dichloromethane are added
3. 3
   ExtracciónThe aqueous sodium phase is extracted twice with dichloromethane
4. 4
   Lavadowashed with water
5. 5
   Secadodried over magnesium sulphate
6. 6
   Otrothe solvent is evaporated under reduced pressure

Procedimiento

31.5 g of the tert-butyl ester of 4-[4-(4-(methanesulphonyl)piperazin-1-yl)phenyl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid are placed in 400 ml of dichloromethane and then 333 ml of 4N hydrochloric acid in dioxane are added. After stirring for 16 h under an inert atmosphere, the solvents are evaporated under reduced pressure. Water, a saturated aqueous sodium hydrogencarbonate solution and dichloromethane are added. The aqueous sodium phase is extracted twice with dichloromethane. The organic phases are combined, washed with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure. 23.2 g of 1-[4-(4-(methanesulphonyl)piperazin-1-yl)phenyl]-1,2,3,4-tetrahydroquinoxaline are obtained. The product is subsequently used as is without other purification.

Fuente