Reacción #69969

Ecuación de reacción

Water

methanesulphonyl chloride

1-(4-bromophenyl)piperazine

triethylamine

→

1-(4-Bromophenyl)-4-(methanesulphonyl)piperazine

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe organic phase is washed twice with water
2. 2
   Secadodried over magnesium sulphate
3. 3
   Otrothe solvent is evaporated under reduced pressure
4. 4
   Otroto result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine
5. 5
   Otroas is without other purification

Procedimiento

7.7 ml of methanesulphonyl chloride are added to a solution of 20 g of 1-(4-bromophenyl)piperazine and 17.34 ml of triethylamine in 394 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 4 h. Water is subsequently added and the organic phase is washed twice with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine. The product is subsequently used as is without other purification.

Fuente