Reacción #698778

Ecuación de reacción

ethyl bromopyruvate

2-imino-4-thiobiuret

→

ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture is heated
2. 2
   Temperaturaunder reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991))
3. 3
   Otrothe reaction product is precipitated by the addition of 550 ml of ethyl acetate
4. 4
   Filtraciónfiltered off

Procedimiento

13.9 ml of ethyl bromopyruvate are added to a solution of 11.81 g of 2-imino-4-thiobiuret (Aldrich) in 100 ml of ethanol and the reaction mixture is heated under reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991)). Subsequently, the mixture is cooled to room temperature and the reaction product is precipitated by the addition of 550 ml of ethyl acetate and filtered off. There are obtained 14.6 g of yellowish ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide. MS: 214 (M)+.

Fuente