Reacción #696727

Ecuación de reacción

3-cyclopentene-1-carboxylic acid

triethylamine

diphenylphosphoryl azide

t-butanol

→

tert-Butyl N-(3-cyclopenten-1-yl)carbamate

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe solution was maintained at 60
2. 2
   workup.WAITcontinued at ambient temperature for 18 hours
3. 3
   OtroVolatiles were evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in methylene chloride (1250 mL)
5. 5
   Lavadowashed with 10 % aqueous sodium carbonate (2×250 mL)
6. 6
   Secadodried (magnesium sulfate)
7. 7
   OtroVolatiles were evaporated
8. 8
   Otrothe residue was chromatographed on a silica gel column
9. 9
   LavadoTitle compound was eluted with chloroform as white crystals, from hexanes (22.63 g, 47%), m.p. 68-70° C.

Procedimiento

To a solution of 3-cyclopentene-1-carboxylic acid (J.-P. Depres and A. E. Greene, J. Org. Chem. 1984, 49:928-931; 29.71 g, 0.261 mole), triethylamine (36.4 mL) in t-butanol (1 L) was added diphenylphosphoryl azide, Aldrich, 97%, 74.0 g, 0.261 mmole). The solution was maintained at 60--C. for 4 hours. Cuprous chloride (1.3 g) was added and stirring continued at ambient temperature for 18 hours. Volatiles were evaporated and the residue was dissolved in methylene chloride (1250 mL) and washed with 10 % aqueous sodium carbonate (2×250 mL) and dried (magnesium sulfate). Volatiles were evaporated and the residue was chromatographed on a silica gel column. Title compound was eluted with chloroform as white crystals, from hexanes (22.63 g, 47%), m.p. 68-70° C.

Fuente