Reacción #6945

Ecuación de reacción

4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

DMF-DMA

→

desired product

4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe resulting mixture heated
2. 2
   Temperaturaat reflux for 18 hours
3. 3
   ConcentraciónThe reaction was concentrated
4. 4
   Otrothe residue triturated with diethyl ether (20 mL)
5. 5
   FiltraciónThe suspension was filtered
6. 6
   Lavadowashed with ether

Procedimiento

To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.

Fuente