Reacción #691384

Ecuación de reacción

pyridine

acetyl chloride

6-Aminohexanoic acid methyl ester hydrochloride

hydrochloric acid

→

methyl 6-acetylamino-hexanoate

Disolventes

methylene chloride

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe mixture is separated
2. 2
   Lavadothe organic layer is washed with a saturated brine
3. 3
   Secadodried over magnesium sulfate
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

6-Aminohexanoic acid methyl ester hydrochloride (5 g) is dissolved in methylene chloride (20 ml) and thereto are added pyridine (4.5 ml) and acetyl chloride (2 ml), and the mixture is stirred at room temperature for 1 hour and 45 minutes. To the reaction solution are added a 1N-hydrochloric acid and chloroform, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give methyl 6-acetylamino-hexanoate (5.19 g) as a crude product. MS (m/z): 188 [M+H]+

Fuente