Reacción #69128

Ecuación de reacción

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

→

title compound

Rendimiento 61.0%

(R)-tert-butyl 1-(4-hydroxycyclohexyl)ethylcarbamate

Rendimiento 61.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe rhodium catalyst was filtered off
2. 2
   Concentraciónthe mother liquors were concentrated in vacuo
3. 3
   OtroThe residue was purified on silica gel by flash column chromatography

Procedimiento

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate (described in the literature: WO 2007035154 (A1)) (100 mg, 0.4214 mmol) was dissolved in methanol (5 mL). A methanolic (5 mL) solution of rhodium on alumina (10 Wt %, 10 mg) was added. The reaction mixture was place under a hydrogen atmosphere and stir at room temperature for 18 hours. The rhodium catalyst was filtered off and the mother liquors were concentrated in vacuo. The residue was purified on silica gel by flash column chromatography to afford the title compound (62 mg, 61% yield).

Fuente