Reacción #689968

Ecuación de reacción

2-methyl-benzooxazole

NBS

→

2-bromomethyl-benzooxazole

Rendimiento 17.0%

Disolventes

CCl4

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathen cooled
2. 2
   FiltraciónSuccinimide was filtered off
3. 3
   Otrothe mixture was evaporated to dryness

Procedimiento

A solution of 35 g (0.263 mol) of 2-methyl-benzooxazole in CCl4 (300 mL) was treated with 47 g (0.263, 1 eq) of NBS and 1 g of benzoyl peroxide. The mixture was refluxed (100° C.) over night then cooled. Succinimide was filtered off and the mixture was evaporated to dryness. Column chromatography yielded 9.2 g (17%) of 2-bromomethyl-benzooxazole as a light yellow oil, MS: 210, 212 (MH+). (H. Uno, M. Kurokawa, Y. Masuda, Chem. Pharm. Bull., 1981, 29, 2359).

Fuente