Reacción #68957

Ecuación de reacción

5-(8-bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile

N-(2-aminoethyl)morpholine

→

title compound

5-(8-(2-morpholinoethylamino)isoquinolin-3-ylamino)pyrazine-2-carbonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothose described in Synthesis 5-1
2. 2
   Otrothe reaction at 140° C.

Procedimiento

The title compound was prepared using methods analogous to those described in Synthesis 5-1, replacing 3,8-dichloroisoquinoline with 5-(8-bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile and replacing (R)-5-amino-3-(pyrrolidin-3-yloxy)pyrazine-2-carbonitrile with N-(2-aminoethyl)morpholine, and conducting the reaction at 140° C.

Fuente