Reacción #6892

Ecuación de reacción

product

6-nitro-2-piperidin-1-ylquinoline

→

product

2-piperidin-1-ylquinolin-6-amine

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resulting mixture was degassed
2. 2
   workup.DISSOLUTIONhad dissolved
3. 3
   FiltraciónThe reaction mixture was filtered
4. 4
   Filtraciónthrough filter aid
5. 5
   Otrothe solvent removed under vacuum

Procedimiento

The product (204 mg, 0.8 mmol) of Step C and palladium hydroxide on carbon (100 mg) was suspended in methanol. The resulting mixture was degassed then stirred under hydrogen atmosphere (balloon) until all the yellow solids had dissolved. The reaction mixture was filtered through filter aid and the solvent removed under vacuum to afford the product as a brown solid, MS: m/z 228 (MH+), which was used without further purification

Fuente