Reacción #68747

Ecuación de reacción

2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone

→

2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

Disolventes

acetone

hydrochloric acid

water

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe crude product is extracted with ethyl acetate (3×15 ml)
2. 2
   Lavadowashed with brine (10 ml)
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Otrothe filtrate is evaporated to dryness under reduced pressure

Procedimiento

A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.

Fuente