Reacción #6866

Ecuación de reacción

product

Methyl 4-Imidazoleacetate

chlorotriphenylmethane

Et3N

→

product

Rendimiento 104.0%

Methyl 1-triphenylmethyl-4-imidazoleacetate

Rendimiento 104.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe DMF was evaporated under reduced pressure
2. 2
   SecadoThe EtOAc layer was dried over Na2SO4
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

A solution of the product from Step 4.a. (3.2 g, 17.5 mmol) in DMF (50 ml) was treated with chlorotriphenylmethane (4.88 g, 17.5 mmol) and Et3N (5.4 ml, 38.5 mmol) and the reaction was stirred at room temperature for about 6 hours. The DMF was evaporated under reduced pressure and the residue was distributed between EtOAc and saturated NaCl solution. The EtOAc layer was dried over Na2SO4, filtered and concentrated under reduced pressure to yield product as a viscous oil (6.96 g, 104%) which crystallized on standing. Mass spec. 383.3 MH+.

Fuente