Reacción #68612

Ecuación de reacción

4-bromo-1H-pyrazole

2,2,2-trifluoroethyl trifluoromethanesulfonate

cesium carbonate

1,4-dioxane

→

4-bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole

Rendimiento 77.1%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrocapped
2. 2
   FiltraciónThe reaction mixture was filtered
3. 3
   Lavadothe solid washed with dioxane
4. 4
   Concentraciónthe filtrate was then concentrated

Procedimiento

A 250 mL RB flask was charged with 4-bromo-1H-pyrazole (2.00 g, 13.6 mmol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (2.35 ml, 17.0 mmol), cesium carbonate (8.87 g, 27.2 mmol), and 1,4-dioxane (40.0 ml, 468 mmol), capped, and stirred at room temperature for 20 hours. The reaction mixture was filtered and the solid washed with dioxane; the filtrate was then concentrated to give 4-bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole (2.402 g, 77.1% yield) as a crude oil.

Fuente