Reacción #685701

Ecuación de reacción

2,4,5-trifluoroaniline

potassium ethylxanthogenate

HCl

→

titled compound

Rendimiento 40.0%

5,6-Difluoro-benzothiazole-2-thiol

Rendimiento 40.0%

Disolventes

N,N-dimethylformamide

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was cooled to room temperature
2. 2
   FiltraciónThe precipitate was collected by filtration
3. 3
   Lavadowashed with water
4. 4
   Otrodried

Procedimiento

A mixture of 1 g (6.80 mmol) 2,4,5-trifluoroaniline and 1.33 g (8.16 mmol) potassium ethylxanthogenate in 5 mL dry N,N-dimethylformamide was heated in a 95° C. oil bath for 7 h. The reaction mixture was cooled to room temperature and diluted with water (15 mL). The mixture was acidified with aqueous HCl 2N. The precipitate was collected by filtration, washed with water and dried to provide 0.55 g (40%) of the titled compound as a light yellow solid. MS(m/e): 201.9 (M−H+).

Fuente