Reacción #68536

Ecuación de reacción

5-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

diphenyl ether

→

Methoxy-1H-[1,5]naphthyridin-4-one

Disolventes

hexane

hexane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA two-necked round bottomed flask equipped with an air condenser
2. 2
   Temperaturawas cooled to RT
3. 3
   Filtraciónfiltered
4. 4
   Otroto obtain a dark solid
5. 5
   Filtraciónfiltered
6. 6
   Otroto obtain product as a brown solid

Procedimiento

A two-necked round bottomed flask equipped with an air condenser was charged with 5-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (18 g) and diphenyl ether (180 mL). The reaction mixture was heated at 240-250° C. for 5 min under N2 atmosphere after which it was cooled to RT, diluted with hexane and filtered to obtain a dark solid. The crude product was refluxed in hexane for 30 min and filtered to obtain product as a brown solid.

Fuente