Reacción #684993

Ecuación de reacción

hydrochloric acid

3-azetidinol trifluoroacetate

potassium carbonate

3-(2-(3-chloropropoxy)ethyl)-1-benzothiophene

→

achromatic oil

Rendimiento 48.1%

1-(3-(2-(1-benzothiophene-3-yl)ethoxy)propyl)-3-azetidinol

Rendimiento 48.1%

Disolventes

dimethyl sulfoxide

ethyl acetate

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Otroa water layer was then separated
3. 3
   workup.ADDITIONEthyl acetate was added to the water layer
4. 4
   workup.ADDITIONthe pH of the obtained mixture was adjusted to pH 10 by addition of a 2 mol/l aqueous sodium hydroxide solution
5. 5
   Otrofollowed by separation of an organic layer
6. 6
   LavadoThe organic layer was successively washed with water
7. 7
   Secadoa saturated saline solution, and then dried over anhydrous magnesium sulfate
8. 8
   workup.DISTILLATIONThereafter, the solvent was distilled away under a reduced pressure
9. 9
   OtroThe residue was purified by column chromatography (eluent; chloroform:methanol=30:1 to 10:1)

Procedimiento

1.00 g of 3-(2-(3-chloropropoxy)ethyl)-1-benzothiophene was dissolved in 5 ml of dimethyl sulfoxide. Thereafter, 1.10 g of 3-azetidinol trifluoroacetate and 1.63 g of potassium carbonate were added to the obtained solution, and the mixture was then stirred at 70° C. for 2 hours. After cooling, water and ethyl acetate were added to the reaction mixture. The pH of the mixture was adjusted to pH 1 by addition of 6 mol/l hydrochloric acid, and a water layer was then separated. Ethyl acetate was added to the water layer, and the pH of the obtained mixture was adjusted to pH 10 by addition of a 2 mol/l aqueous sodium hydroxide solution, followed by separation of an organic layer. The organic layer was successively washed with water and a saturated saline solution, and then dried over anhydrous magnesium sulfate. Thereafter, the solvent was distilled away under a reduced pressure. The residue was purified by column chromatography (eluent; chloroform:methanol=30:1 to 10:1), so as to obtain 0.55 g of an achromatic oil product, 1-(3-(2-(1-benzothiophene-3-yl)ethoxy)propyl)-3-azetidinol.

Fuente