Reacción #684975

Ecuación de reacción

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

Rendimiento 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

Rendimiento 84.4%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe reaction mixture was washed with saturated brine
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   OtroThe residue was purified by silica gel column chromatography

Procedimiento

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

Fuente