Reacción #684974

Ecuación de reacción

ethyl acetate

Trifluoroacetic acid

compound

2-(4-Bromo-2-fluorobenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

→

title compound

Rendimiento 84.1%

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

Rendimiento 84.1%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   LavadoThe ethyl acetate layer was washed with saturated brine
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   OtroThe residue was purified by silica gel column chromatography

Procedimiento

Trifluoroacetic acid (1 ml) was added to the compound of Example B244 (134 mg, 0.411 mmol) in methylene chloride (4 ml), and this reaction mixture was stirred at room temperature overnight. After neutralizing the mixture with saturated aqueous sodium hydrogencarbonate, ethyl acetate was added. The ethyl acetate layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (97.5 mg).

Fuente