Reacción #684971

Ecuación de reacción

Trifluoroacetic acid

compound

2-(4-Butylbenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

ethyl acetate

→

title compound

Rendimiento 88.8%

2-(4-Butylbenzyl)-3-pyridinol

Rendimiento 88.8%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe reaction mixture was washed with saturated brine
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   OtroThe residue was purified by silica gel column chromatography

Procedimiento

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

Fuente