Reacción #684970

Ecuación de reacción

Potassium carbonate

methyl iodide

compound

1-(4-Bromo-2-hydroxyphenyl)-1-butanone

→

title compound

Rendimiento 67.7%

1-(4-Bromo-2-methoxyphenyl)-1-butanone

Rendimiento 67.7%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawhile heating
2. 2
   Temperaturaunder reflux for 4 hours
3. 3
   FiltraciónThe reaction mixture was filtered through celite, ether
4. 4
   workup.ADDITIONwas added
5. 5
   Otroto remove insoluble material
6. 6
   Filtraciónby filtration
7. 7
   Concentraciónthe filtrate was concentrated under reduced pressure
8. 8
   OtroThe residue was purified by silica gel column chromatography

Procedimiento

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

Fuente