Reacción #684969

Ecuación de reacción

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

Rendimiento 80.1%

4-Bromo-1-isoquinolinol

Rendimiento 80.1%

Disolventes

tetrahydrofuran

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe resulting reaction mixture
2. 2
   Filtraciónwas filtered
3. 3
   Filtraciónthrough filter paper
4. 4
   LavadoThe organic layer was washed with saturated brine
5. 5
   Concentraciónconcentrated under reduced pressure
6. 6
   OtroThe residue was recrystallized from ethyl acetate and hexane

Procedimiento

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

Fuente