Reacción #684965

Ecuación de reacción

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

Rendimiento 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

Rendimiento 94.6%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 19 hours
2. 2
   ConcentraciónThe mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   Otroto precipitate crystals
5. 5
   FiltraciónThe obtained crystals were collected by filtration
6. 6
   Lavadowashed with water
7. 7
   Otrodried

Procedimiento

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

Fuente