Reacción #684953

Ecuación de reacción

ethynylbenzene

pyrrolidine

pyrrolidine

→

title compound

1-[2-(2-Phenyl-1-ethynyl)benzyl]isoquinoline

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was cooled to room temperature
2. 2
   Lavadowashed with a saturated aqueous ammonium chloride solution
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   Concentraciónconcentrated under reduced pressure
5. 5
   OtroThe residue was purified by silica gel chromatography

Procedimiento

A solution of tetrakis(triphenylphosphine)palladium (58 mg, 0.05 mmol) and ethynylbenzene (204 mg, 2.0 mmol) in pyrrolidine (1.5 ml) was added to a solution of the compound of Example B25 (345 mg, 1.07 mmol) in pyrrolidine (1.5 ml) under nitrogen atmosphere, and the mixture was stirred at 80° C. for 3 hours. The mixture was cooled to room temperature, diluted with ethyl acetate, washed with a saturated aqueous ammonium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel chromatography to give the title compound (280 mg).

Fuente