Reacción #684952

Ecuación de reacción

sodium hydrogencarbonate

Methanesulfonyl chloride

triethylamine

o-iodobenzyl alcohol

→

title compound

Rendimiento 100.7%

1-(Chloromethyl)-2-iodobenzene

Rendimiento 100.7%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe resulting mixture was extracted with methylene chloride
2. 2
   SecadoThe methylene chloride layer was dried over anhydrous magnesium sulfate
3. 3
   Concentraciónconcentrated under reduced pressure

Procedimiento

Methanesulfonyl chloride (2.0 ml, 29 mmol) and triethylamine (3.6 ml, 26 mmol) were added to a solution of o-iodobenzyl alcohol (5.0 g, 21 mmol) in methylene chloride (50 ml) cooled to 0° C., and the mixture was stirred at that temperature for 19 hours. A 5% aqueous sodium hydrogencarbonate solution was added, and the resulting mixture was extracted with methylene chloride. The methylene chloride layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (5.34 g).

Fuente