Reacción #68421

ord-55f9e6fabcba425ab1c1072f1aee8be9

Ecuación de reacción

COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
Compound 137
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
BrCc1cccnc1
3-(bromomethyl)pyridine
BrC1CCC1
cyclobutyl bromide
Br
HBr
NCc1ccc(F)c(F)c1
3,4-difluorobenzylamine
→
CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(OC3CCC3)cc2n1Cc1cccnc1
title compound
CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(OC3CCC3)cc2n1Cc1cccnc1
6-Cyclobutoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide

Reactantes

COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
Compound 137
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
BrCc1cccnc1
3-(bromomethyl)pyridine
BrC1CCC1
cyclobutyl bromide
Br
HBr
NCc1ccc(F)c(F)c1
3,4-difluorobenzylamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared from 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137), 3-(bromomethyl)pyridine.HBr, 3,4-difluorobenzylamine, and cyclobutyl bromide by, in order, General Procedure J, General Procedure K, General Procedure C, General Procedure L, and General Procedure N.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08524917B2uspto-grants-2013_09