Reacción #68418

ord-164e0292d7c940bb90896a1cf1027007

Ecuación de reacción

COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
Compound 137
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
BrCc1cccnc1
3-(bromomethyl)pyridine
NCc1cncc(F)c1
Compound 145
NCc1cncc(F)c1
(5-fluoropyridin-3-yl)methanamine
Br
HBr
NCc1cncc(F)c1
(5-fluoropyridin-3-yl)methanamine
→
CC(C)c1c(C(=O)NCc2cncc(F)c2)c2ccc(O)cc2n1Cc1cccnc1
title compound
CC(C)c1c(C(=O)NCc2cncc(F)c2)c2ccc(O)cc2n1Cc1cccnc1
N-((5-Fluoropyridin-3-yl)methyl)-6-hydroxy-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide

Reactantes

COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
Compound 137
COc1ccc2c(C=O)c(C(C)C)[nH]c2c1
2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde
BrCc1cccnc1
3-(bromomethyl)pyridine
NCc1cncc(F)c1
Compound 145
NCc1cncc(F)c1
(5-fluoropyridin-3-yl)methanamine
Br
HBr
NCc1cncc(F)c1
(5-fluoropyridin-3-yl)methanamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared from 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137), 3-(bromomethyl)pyridine.HBr, and (5-fluoropyridin-3-yl)methanamine (Compound 145) by, in order, General Procedure J, General Procedure K, General Procedure C, and General Procedure L.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08524917B2uspto-grants-2013_09