Reacción #68008

Ecuación de reacción

4-chloro-7-trifluoromethylquinoline

m-chloroperbenzoic acid

sodium hydrogen carbonate

→

4-chloro-7-trifluoromethylquinoline N-oxide

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   OtroThe organic layer was separated
3. 3
   Extracciónthe aqueous layer was extracted with chloroform
4. 4
   Lavadothe resultant solution was washed with an aqueous saturated sodium chloride solution
5. 5
   Secadodried over anhydrous magnesium sulfate
6. 6
   Otrothe solvent was removed under reduced pressure

Procedimiento

To 14 mL of a chloroform solution containing 0.90 g of 4-chloro-7-trifluoromethylquinoline, 1.04 g of m-chloroperbenzoic acid was added, and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was added with 15 mL of an aqueous saturated sodium hydrogen carbonate solution. The organic layer was separated, and the aqueous layer was extracted with chloroform. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain a yellow solid, 4-chloro-7-trifluoromethylquinoline N-oxide.

Fuente