Reacción #67999

Ecuación de reacción

trifluoroacetic acid

1-(1,3-dioxolan-2-ylmethyl)-6-methyl-2-oxo-1,2-dihydroquinoline

→

(6-methyl-2-oxoquinolin-1(2H)-yl)acetaldehyde

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed under reduced pressure
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe organic layer was washed sequentially with water
4. 4
   Secadoan aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate
5. 5
   Otrothe solvent was removed under reduced pressure

Procedimiento

Into 3 mL of a 90% aqueous trifluoroacetic acid solution, 243 mg of 1-(1,3-dioxolan-2-ylmethyl)-6-methyl-2-oxo-1,2-dihydroquinoline was dissolved, and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, the resultant solution was alkalified with an aqueous saturated sodium hydrogen carbonate solution, and then extracted with ethyl acetate. The organic layer was washed sequentially with water and an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 236 mg of a pale yellow oily substance, (6-methyl-2-oxoquinolin-1(2H)-yl)acetaldehyde.

Fuente