Reacción #67989

Ecuación de reacción

methyl 3-oxo-3-(1,3-thiazol-2-yl)propionate

m-anisidine

→

N-(3-methoxyphenyl)-3-oxo-3-(1,3-thiazol-2-yl)propaneamide

Disolventes

xylene

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturaunder reflux
3. 3
   Temperaturaby heating
4. 4
   OtroThe solvent was removed under reduced pressure, and water and ethyl acetate
5. 5
   workup.ADDITIONwere added
6. 6
   OtroThe organic layer was separated
7. 7
   Extracciónthe aqueous layer was extracted with ethyl acetate
8. 8
   Lavadothe resultant solution was washed with an aqueous saturated sodium chloride solution
9. 9
   Secadodried over anhydrous magnesium sulfate
10. 10
    Otrothe solvent was removed under reduced pressure

Procedimiento

To 30 mL of a xylene solution containing 2.3 g of methyl 3-oxo-3-(1,3-thiazol-2-yl)propionate, 1.4 mL of m-anisidine was added. The reaction mixture was stirred for 6 hours under reflux by heating. The solvent was removed under reduced pressure, and water and ethyl acetate were added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 3.3 g of a brown oily substance, N-(3-methoxyphenyl)-3-oxo-3-(1,3-thiazol-2-yl)propaneamide.

Fuente