Reacción #67962

Ecuación de reacción

1-tert-butyl 3-ethyl 4-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-1,3-dicarboxylate

hydrogen chloride ethanol

water

→

ethyl 1-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-2-carboxylate

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvent was removed under reduced pressure
2. 2
   OtroThe residue thus obtained
3. 3
   OtroThe aqueous layer was separated
4. 4
   workup.ADDITIONethyl acetate was added
5. 5
   OtroThe organic layer was separated
6. 6
   Secadodried over potassium carbonate
7. 7
   Otrothe solvent was removed under reduced pressure

Procedimiento

To 0.60 g of 1-tert-butyl 3-ethyl 4-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-1,3-dicarboxylate, 12 mL of 10 mol/L hydrogen chloride/ethanol was added, and the mixture was stirred for 2 hours, and then the solvent was removed under reduced pressure. The residue thus obtained was added with water and ethyl acetate. The aqueous layer was separated, ethyl acetate was added thereto, and the resultant solution was adjusted to pH 14 with a 5 mol/L aqueous sodium hydroxide solution. The organic layer was separated and dried over potassium carbonate, and the solvent was removed under reduced pressure to obtain 0.34 g of a brown oily substance, ethyl 1-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-2-carboxylate.

Fuente