Reacción #6792

Ecuación de reacción

water

2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine

tetrahydro-2H-pyran-4-amine

→

title compound

Rendimiento 40.0%

4-[4-(methylsulfonyl)phenyl]-N-tetrahydro-2H-pyran-4-yl-6-(trifluoromethyl)pyrimidin-2-amine

Rendimiento 40.0%

Disolventes

N-methylpyrrolidone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThis resulted in a precipitate
2. 2
   Otrobeing formed
3. 3
   Filtraciónwhich was collected by filtration
4. 4
   Otrodried in vacuo (0.258 g)
5. 5
   OtroThis material was then purified by autopurification

Procedimiento

To a solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (0.277 g, 0.73 mmol) in N-methylpyrrolidone (1.25 ml) was added tetrahydro-2H-pyran-4-amine (0.147 g, 2 eq.), the mixture was stirred for 1 hour and then water (1.25 ml) was added dropwise. This resulted in a precipitate being formed, which was collected by filtration, and dried in vacuo (0.258 g). This material was then purified by autopurification to give the title compound as a colourless solid (0.116 g, 40%).

Fuente