Reacción #6782

Ecuación de reacción

4-carboxyindole

2-chloro-1-methylpyridinium iodide

4-phenethylpiperazine

ethyldi-isopropylamine

→

(1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride

Rendimiento 100.1%

Disolventes

acetone

N-methylpyrrolidone

NMP

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe crude product is obtained
2. 2
   Otrothe hydrochloride is precipitated
3. 3
   OtroAfter drying

Procedimiento

A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.

Fuente