Reacción #67624

Ecuación de reacción

Intermediate ( II )

8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxy ethy)quinolin-2(1H)-one

→

title compound

Rendimiento 54.3%

5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one

Rendimiento 54.3%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst was filtered through Celite
2. 2
   Concentraciónthe solvent concentrated
3. 3
   OtroThe resulting oil was purified by column chromatography with silica gel eluting with methylene chloride/methanol (95:5)

Procedimiento

To Intermediate (II) (1.10 g, 2.0 mmol) in methanol (50 mL) was added 20% palladium on charcoal (300 mg). The mixture was hydrogenated at 2 bars for 3 hours. The catalyst was filtered through Celite and the solvent concentrated. The resulting oil was purified by column chromatography with silica gel eluting with methylene chloride/methanol (95:5) to give the title compound (0.50 g, 54%) as oil.

Fuente