Reacción #67494

Ecuación de reacción

3-aminopropionic acid methyl ester hydrochloride

1-chlorocarbonyloctahydroquinoline

AcOEt

→

intermediate

Rendimiento 67.1%

3-[(octahydroquinoline-1-carbonyl)amino]propionic acid methyl ester

Rendimiento 67.1%

Disolventes

THF

Et3N

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONOnce dissolved
2. 2
   Temperaturait is refluxed for 18 h
3. 3
   Lavadothe resulting solution is sequentially washed with water, 1N HCl and brine
4. 4
   SecadoThe organic phase is dried over anhydrous Na2SO4, it
5. 5
   Filtraciónis filtered
6. 6
   Otrothe solvent is evaporated under reduced pressure

Procedimiento

0.5 g (3.5 mmol) of the 3-aminopropionic acid methyl ester hydrochloride are dissolved in 5 mL of anhydrous THF and 0.9 mL of Et3N. Once dissolved, 650 mg of 1-chlorocarbonyloctahydroquinoline are slowly added and it is refluxed for 18 h. AcOEt is then added and the resulting solution is sequentially washed with water, 1N HCl and brine. The organic phase is dried over anhydrous Na2SO4, it is filtered and the solvent is evaporated under reduced pressure yielding 580 mg of intermediate IIIb.1.

Fuente