Reacción #674287

ord-9fb1ff1cb2d94f1da5086a474289cc48

Ecuación de reacción

[Ca+2].[Cl-].[Cl-]
calcium chloride
O=P([O-])([O-])O
hydrogen phosphate
[Na+].[OH-]
NaOH
→
O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2]
Calcium Phosphate

Reactantes

[Ca+2].[Cl-].[Cl-]
calcium chloride
O=P([O-])([O-])O
hydrogen phosphate
[Na+].[OH-]
NaOH

Reactivos

Ninguno

Disolventes

O=P([O-])([O-])[O-]
phosphate

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroCaP NPs
  2. 2
    Otrowere obtained by filtration of the suspension through a 0.22 μm
  3. 3
    Filtraciónfilter
  4. 4
    OtroCaP NPs
  5. 5
    Otrowere stored at 4° C. before use
  6. 6
    OtroCaP/ZOL-NPs complexes (CaPZ NPs) were prepared

Procedimiento

An aqueous solution of calcium chloride (18 mM) was added, dropwise and under magnetic stirring, to an aqueous solution on dibasic hydrogen phosphate (10.8 mM). The pH of both solutions was adjusted beforehand to 9.5 with NaOH. CaP NPs were obtained by filtration of the suspension through a 0.22 μm filter. CaP NPs were stored at 4° C. before use. CaP/ZOL-NPs complexes (CaPZ NPs) were prepared by mixing a CaP NPs dispersion with an aqueous solution of (50 mg/ml of ZOL in phosphate buffer at pH 9.5), at a volume ratio of 50:1.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09226897B2uspto-grants-2016_01