Reacción #67305

Ecuación de reacción

(7-bromo-5-chloro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol

sodium methanesulfinate

L-proline

K2CO3

→

[(2S)-5-CHLORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHANOL

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroPreparation
2. 2
   OtroYield (0.33 g)

Procedimiento

Preparation according to Preparation 9 using (7-bromo-5-chloro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol (1.07 g, 3.8 mmol), sodium methanesulfinate (85%) (0.6 g, 5.7 mmol), CuI (0.07 g, 0.4 mmol), L-proline (0.09 g, 0.8 mmol) and K2CO3 (0.04 g, 0.8 mmol) in DMSO (10 ml). Yield (0.33 g). MS m/z (rel. intensity, 70 eV) 280 (38), 278 (M+, bp), 247 (35), 207 (18), 57 (18).

Fuente