Reacción #67303

Ecuación de reacción

1-[5-bromo-3-chloro-2-(oxiran-2-ylmethoxy)phenyl]ethanone

m-CPBA

m-CPBA

→

crude title compound

Rendimiento 149.9%

5-BROMO-3-CHLORO-2-(OXIRAN-2-YLMETHOXY)PHENYL ACETATE

Rendimiento 149.9%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrobrought to ambient temperature
2. 2
   FiltraciónThe solid was filtered off
3. 3
   Lavadorinsed
4. 4
   LavadoThe resulting filtrate was washed with sodium bicarbonate (saturated), brine
5. 5
   Secadofurther dried (Na2SO4)
6. 6
   Otroevaporated to dryness

Procedimiento

A solution of 1-[5-bromo-3-chloro-2-(oxiran-2-ylmethoxy)phenyl]ethanone (1.7 g, 5.6 mmol) and m-CPBA (2.4 g, 14 mmol) in DCM (30 ml) was heated to 50° C. After 22 h more m-CPBA (2.4 g, 14 mmol) was added and the mixture was heated at 50° C. for another 44 h and then brought to ambient temperature. The solid was filtered off and rinsed. The resulting filtrate was washed with sodium bicarbonate (saturated), brine and further dried (Na2SO4) and evaporated to dryness to give the crude title compound (2.7 g). MS m/z (rel. intensity, 70 eV) 280 (bp), 278 (84), 224 (54), 222 (52), 57 (79), 322 (M+, 5).

Fuente