Reacción #67291

ord-1acb426b52e149b98ebdc866b3fc5ae3

Ecuación de reacción

CC(=O)Oc1cc(S(=O)(=O)C(F)(F)F)ccc1OC[C@H]1CO1
2-[(2R)-oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl acetate
[K+].[OH-]
KOH
→
O=S(=O)(c1ccc2c(c1)O[C@@H](CO)CO2)C(F)(F)F
[(2S)-7-(TRIFLUOROMETHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHANOL

Reactantes

—
( 67 )
CC(=O)Oc1cc(S(=O)(=O)C(F)(F)F)ccc1OC[C@H]1CO1
2-[(2R)-oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl acetate
[K+].[OH-]
KOH
—
( 33 )
—
( 72 )

Reactivos

Ninguno

Disolventes

C1COCCO1
dioxane

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPreparation

Procedimiento

Preparation according to Preparation 20 using 2-[(2R)-oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl acetate (1.0 g, 3.7 mmol), dioxane (10 ml) and KOH (10%, 10 ml), the mixture stirred at RT for 1 h. Yield 1.0 g. MS m/z (rel. intensity, 70 eV) 298 (M+, 29), 229 (72), 165 (bp), 107 (67), 79 (33).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08524766B2uspto-grants-2013_09