Reacción #67283

Ecuación de reacción

5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxyphenyl)ethanone

m-CPBA

→

5-BROMO-3-FLUORO-2-[(2R)-OXIRAN-2-YLMETHOXY]PHENYL ACETATE

Disolventes

CHCl3

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroPreparation
2. 2
   TemperaturaThe mixture was heated
3. 3
   Temperaturaat reflux for 24 h
4. 4
   Otro(Preparation 25)

Procedimiento

Preparation according to Preparation 7 using 1-(5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxyphenyl)ethanone (19.5 g, 67 mmol), CHCl3 and m-CPBA (77%, 60.5 g, 27 mmol). The mixture was heated at reflux for 24 h. The crude product was further used (Preparation 25). MS m/z (rel. intensity, 70 eV) 306 (M+, 4), 304 (M+, 4) 262 (bp), 69 (69), 57 (99).

Fuente