Reacción #67278

Ecuación de reacción

1-[5-bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl]ethanone

m-CPBA

m-CPBA

→

crude title compound

Rendimiento 189.4%

5-BROMO-3-FLUORO-2-(OXIRAN-2-YLMETHOXY)PHENYL ACETATE

Rendimiento 189.4%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux
2. 2
   Temperaturathe mixture was heated
3. 3
   Temperaturaat reflux for another 22 h
4. 4
   Otrobrought to ambient temperature
5. 5
   FiltraciónThe solid was filtered off
6. 6
   Lavadorinsed
7. 7
   LavadoThe resulting filtrate was washed with sodium bicarbonate (saturated), brine
8. 8
   Secadofurther dried (Na2SO4)
9. 9
   Otroevaporated to dryness

Procedimiento

A solution of 1-[5-bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl]ethanone (1.3 g, 4.5 mmol) and m-CPBA (4.0 g, 18 mmol) in DCM (25 ml) was heated at reflux. After 22 h more m-CPBA (2.7 g, 12 mmol) was added and the mixture was heated at reflux for another 22 h and then brought to ambient temperature. The solid was filtered off and rinsed. The resulting filtrate was washed with sodium bicarbonate (saturated), brine and further dried (Na2SO4) and evaporated to dryness to give the crude title compound (2.6 g). MS m/z (rel. intensity, 70 eV) 305 (M+, 5), 304 (M+, 6), 263 (97), 262 (bp), 206 (49), 57 (65).

Fuente