Reacción #67262

Ecuación de reacción

KOH

NaOH

5-bromo-2-(oxiran-2-ylmethoxy)phenyl formate

Water

→

title compound

Rendimiento 91.4%

(7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHANOL

Rendimiento 91.4%

Disolventes

dioxane

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe phases were separated
2. 2
   LavadoThe combined organic phases were washed with brine
3. 3
   Otrodried

Procedimiento

5-bromo-2-(oxiran-2-ylmethoxy)phenyl formate (12.6 g, 46.0 mmol) was dissolved in dioxane (50 ml) and KOH (10%)/NaOH (20%) was added. Water and EtOAc was added and the phases were separated. The combined organic phases were washed with brine and dried to give the title compound (10.3 g). MS m/z (rel. intensity, 70 eV) 245 (M+, 96) 244 (M+, bp), 213 (29), 189 (46), 188 (49).

Fuente