Reacción #67230

ord-71528d811fdd4980877dfa4965b6c865

Ecuación de reacción

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
C1CNC1
azetidine
→
CS(=O)(=O)c1cc(Cl)c2c(c1)O[C@@H](CN1CCC1)CO2
1-{[(2S)-5-CHLORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}AZETIDINE

Reactantes

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
—
( 2 )
—
( 3 )
—
( 5 )
—
( 3 )
C1CNC1
azetidine

Reactivos

Ninguno

Disolventes

CC#N
ACN

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPreparation

Procedimiento

Preparation according to Example 57 using [(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.027 g, 0.062 mmol), azetidine (0.1 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 317 (M+, 1), 85 (3), 71 (5), 70 (bp), 68 (2), 63 (3).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08524766B2uspto-grants-2013_09