Reacción #67216

ord-c47250b0eae84e03bb90ec6265356e47

Ecuación de reacción

Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
C1CNC1
azetidine
→
CS(=O)(=O)c1cc(F)c2c(c1)OC(CN1CCC1)CO2
1-{[5-FLUORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}AZETIDINE

Reactantes

—
( 5 )
Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
C1CNC1
azetidine
—
( 4 )
—
( 3 )

Reactivos

Ninguno

Disolventes

CC#N
ACN

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPreparation

Procedimiento

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), azetidine (0.1 ml), ACN (2.5 ml). MS m/z (rel. intensity, 70 eV) 301 (M+, 1), 244 (3), 71 (5), 70 (bp), 69 (4).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08524766B2uspto-grants-2013_09