Reacción #669384

Ecuación de reacción

3-(4-methoxyphenyl)propionic acid

bromine

→

title compound

Rendimiento 87.0%

3-(3-Bromo-4-methoxyphenyl)propionic acid

Rendimiento 87.0%

Disolventes

water

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate
2. 2
   LavadoThe extract was washed serially with saturated saline and water
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
5. 5
   LavadoThe residue was washed with hexane

Procedimiento

To a solution of 3-(4-methoxyphenyl)propionic acid (4.0 g, 22.2 mmol) in acetic acid (20 ml) was added bromine (3.9 g, 24.4 mmol) gradually dropwise at 10° C. and the mixture was stirred at room temperature for 30 minutes. This reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed serially with saturated saline and water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was washed with hexane to provide the title compound (yield 5.0 g, 87%).

Fuente