Reacción #66913

Ecuación de reacción

Compound 51

Dibenzyl 2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl phosphate

compound 49

2-(3-Fluorophenyl)-6-methoxyquinoline-4,5-diyl bis(dihydrogen phosphate)

→

52

Rendimiento 63.7%

2-(3-Fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl dihydrogen phosphate

Rendimiento 63.7%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto react in the same manner

Procedimiento

Compound 51 (0.25 g, 0.46 mmol) was allowed to react in the same manner as described in the preparation of compound 49 to give 52. Yellow solid; yield: 63.7%; mp 179-181° C.; MS (ESI): m/z 366 (M+H)+; 1H-NMR (D2O+NaOD, 200 MHz): δ 3.76 (s, 3H), 6.53 (s, 1H), 7.05 (1, =8.4 Hz, 1H), 7.24-7.60 (m, 5H); Anal. (C16H13FNO6P) C, H, N.

Fuente