Reacción #6682

Ecuación de reacción

KOH

ethyl 4-benzyloxybenzoate

→

4-Benzyloxybenzoic acid

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter the resulting mixture was refluxed for 4 hrs
2. 2
   Otrothe excess methanol was removed
3. 3
   workup.ADDITIONThe residue was mixed with 30 ml water
4. 4
   Extracciónextracted with ether twice
5. 5
   Extracciónextracted with ethyl acetate
6. 6
   LavadoThe ethyl acetate solution was washed with brine
7. 7
   Otrodried
8. 8
   OtroAfter evaporation of solvent
9. 9
   Otropure product was obtained in quantitative yield

Procedimiento

To the solution of 0.5 g KOH in 40 ml MeOH, was added 6.5 mmol of ethyl 4-benzyloxybenzoate. After the resulting mixture was refluxed for 4 hrs, the excess methanol was removed. The residue was mixed with 30 ml water and extracted with ether twice. The water solution was acidified with conc. HCl and extracted with ethyl acetate. The ethyl acetate solution was washed with brine and dried. After evaporation of solvent, pure product was obtained in quantitative yield.

Fuente