Reacción #66814

Ecuación de reacción

ethyl 3-cyano-2-{[(1E)(dimethylamino)methylidene]amino}-4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate

Ethyl 3-cyano-2-{[(1E)-(dimethylamino)methylidene]amino}-4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate

3-ethynylaniline

→

title compound

Ethyl 4-[(3-ethynylphenyl)amino]-5,8-dihydropyrido[4′,3′:4,5]furo[2,3-d]pyrimidine-7(6H)-carboxylate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto yield 443 mg (28%)

Procedimiento

In analogy to Example 38A, the title compound was prepared from ethyl 3-cyano-2-{[(1E)(dimethylamino)methylidene]amino}-4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate from Example 37A (1.20 g, 4.14 mmol) and 3-ethynylaniline (968 mg, 8.27 mmol) to yield 443 mg (28%).

Fuente