Reacción #6673

Ecuación de reacción

phenothiazine

iodoethane

potassium hydroxide

→

10-Ethylphenothiazine

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 24 hours
2. 2
   TemperaturaAfter cooling
3. 3
   Filtraciónthe reaction mixture was filtered
4. 4
   Otrothe solvent was evaporated
5. 5
   OtroThe product was crystallized from methanol

Procedimiento

A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.

Fuente