Reacción #66690

Ecuación de reacción

2-Chloro-N-(2-hydroxy-4-methoxy-phenyl)-acetamide

potassium carbonate

→

7-Methoxy-4H-benzo[1,4]oxazin-3-one

Rendimiento 101.0%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture was refluxed under nitrogen for eight hours
2. 2
   TemperaturaThe reaction mixture was cooled
3. 3
   Otrosolids were removed by filtration
4. 4
   Concentraciónthe liquid was concentrated under reduced pressure

Procedimiento

2-Chloro-N-(2-hydroxy-4-methoxy-phenyl)-acetamide (390.0 g, 0.18 mol) and powdered potassium carbonate (27.6 g, 0.2 mol) were added to 1000 mL acetone, and the reaction mixture was refluxed under nitrogen for eight hours. The reaction mixture was cooled, solids were removed by filtration, and the liquid was concentrated under reduced pressure to give 32.56 g of crude 7-Methoxy-4H-benzo[1,4]oxazin-3-one. (M+H)=180.

Fuente